Palbociclib 125mg

1. Dosage:

- 125 mg.

2. What Palbociclib IPI is and what is it used for:

Palbociclib IPI is an anticancer medicine containing the active substance Palbociclib. Palbociclib works by blocking proteins called cyclin-dependent kinases 4 and 6, which regulate cell growth and division. Blocking these proteins can slow down the growth of cancer cells and delay the progression of your cancer. Palbociclib IPI is used to treat patients with certain types of breast cancer (hormone receptorpositive, human epidermal growth factor receptor 2-negative), which have spread beyond the original tumour and/or to other organs. It is given together with aromatase inhibitors or fulvestrant, which are used as hormonal anticancer therapies.

3. What do you need to know before you take Palbociclib IPI:

Do not take this medicine if:

- if you are allergic to palbociclib or any of the other ingredients of this medicine.

- The use of preparations containing St. John’s Wort, an herbal product used to treat mild depression and anxiety, should be avoided while you are taking Palbociclib IPI.

4. Warnings and Precautions:

Talk to your doctor before taking Palbociclib IPI.

Palbociclib IPI may reduce the number of your white blood cells and weaken your immune system.

Therefore, you may be at greater risk of getting an infection while you are taking Palbociclib IPI. Tell your doctor if you experience signs or symptoms of an infection, such as chills or fever.

You will have regular blood tests during treatment to check whether Palbociclib IPI affects your blood cells.

Palbociclib IPI may cause severe or life-threatening inflammation of the lungs during treatment that can lead to death. Tell your doctor right away if you have any new or worsening symptoms including:

- Difficulty breathing or shortness of breath.

- Dry cough.

- Chest pain.

Children and Adolescents:

Palbociclib IPI is not to be used in children or adolescents (under 18 years of age).

Other Medicines and Palbociclib IPI: Tell your doctor if you are taking, have recently taken, or might take any other medicines. Palbociclib IPI may affect the way some other medicines work.

Palbociclib IPI with food and drink: Avoid grapefruit and grapefruit juice while you are taking Palbociclib IPI as it may increase the side effects of Palbociclib IPI.

Pregnancy and Breastfeeding and Fertility:

- You should not use Palbociclib IPI if you are pregnant.

- You should avoid becoming pregnant while taking Palbociclib IPI.

- Discuss contraception with your doctor if there is any possibility that you or your partner may become pregnant.

- If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

- Women of childbearing potential who are receiving this medicinal product, or their male partners should use adequate contraceptive methods. These methods should be used during therapy and for at least 3 weeks after completing therapy for females and at least 14 weeks for males.

- Breastfeeding: You should not breastfeed while taking Palbociclib IPI.

- Fertility: Palbociclib may decrease fertility in men. Therefore, men may consider sperm preservation before taking Palbociclib IPI.

Driving and Using Machines: Tiredness is a very common side effect of Palbociclib IPI. If you feel unusually tired, take special care when driving or using machines.

5. Possible Side Effects:

Contact your doctor immediately if you have any of these symptoms:

- Fever, chills, weakness, shortness of breath, bleeding, or easy bruising.

- Difficulty breathing, dry cough or chest pain.

Other side effects with palbociclib IPI may include:

Very common side effects (May affect more than 1 in 10 people):

- Infections.

- Reduction in white blood cells, red blood cells, and blood platelets.

- Feeling of tiredness.

- Decreased appetite.

- Inflammation of the mouth and lips, nausea, vomiting, and diarrhoea.

- Rash.

- Hair loss.

- Weakness.

- Fever.

- Abnormalities in liver blood tests.

- Dry skin.

Common side effects (May affect up to 1 in 10 people):

- Fever with a drop in the white blood cell count.

- Blurred vision, increased tearing, dry eye.

- Alteration in taste.

- Nosebleed.

Uncommon side effects (May affect up to 1 in 100 people):

- Inflammation of the skin causing red scaly patches and possibly occurring together with joint pain and fever.

6. How to take Palbociclib IPI:

- Always take this medicine exactly as your doctor has told you.

- The recommended dose is 125 mg of Palbociclib IPI taken once a day for 3 weeks followed by 1 week without taking Palbociclib IPI.

- If you experience certain side effects while you are taking Palbociclib IPI, your doctor may lower your dose or stop treatment, either temporarily or permanently. The dose may be lowered to one of the other available strengths 100 mg or 75 mg.

- Take Palbociclib IPI once a day at about the same time every day with food, preferably a meal.

- Swallow the tablet whole with a glass of water.

- Do not chew or crush the tablets.

If you have taken too much Palbociclib IPI, see a doctor or go to a hospital immediately. Urgent treatment may be necessary.

If you miss a dose or vomit, take your next dose as scheduled. Do not take a double dose to make up for the forgotten tablets.

Do not stop taking Palbociclib IPI unless your doctor tells you to.